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Newly Diagnosed Atrial Fibrillation and Acute Stroke, The Framingham Study Stroke 26:1527-1530, Lin,H.J.,et al, 1995 See this aricle in Pubmed Article Abstract During 38 years of follow-up,115 of 656 initial stroke events occurred in association with AF:89 had previously demonstrated AF,21 had AF discovered for the first time on admission for stroke,and 5 were admitted with sinus rhythm but developed AF after admission.Of the 21 subjects with AF diagnosed on admission,in 12(57%)AF persisted thereafter(chronic AF).Among the other 9 persons presenting with nonpersistent AF,paroxysms recurred in 3(14%)and became chronic AF in 4(19%).AF was transient and did not recur in only 2 persons(10%).Of the 5 subjects who developed AF after admission, AF was sustained from the initial diagnosis in 2 and recurred in paroxysms or became established as chronic in 3.Ninety-two percent(24/26)of subjects presenting with newly discovered AF at the time of acute stroke continued to have this rhythm disturbance in a chronic or paroxysmal form.In only 2 subjects(8%)was the arrhythmia short-lived or nonrecurrent.These follow-up data suggests that in most instances AF was probably the precipitant rather than the consequence of stroke.

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